Publications
**An ABCB11 variant registry and novel knockin mouse model of PFIC2 based on the clinically relevant ABCB11 E297G variant
Eric L Bell 1, Jennifer K Truong 2, Youhwa Jo 2, Adrianne Kolpak 2, Lauren Chunn 3, Natalie Syverud 3, Melida Mahinic 3, Jessica R Durrant 4, Eitan Hoch 2, Bharat Reddy 2, Patrick Stoiber 2, John P Miller 2, Yong Ren 2, Jonathan Moore 2, Robert O Hughes 5, Alastair S Garfield 2
1Rectify Pharmaceuticals, Cambridge, MA, USA
2Genomenon, Ann Arbor, MI, USA
3DTR Labs, Farmers Branch, TX, USA
J Lipid Res, 2025 Jun 11;66(7):100840. doi: 10.1016/j.jlr.2025.100840
https://pmc.ncbi.nlm.nih.gov/articles/PMC12273561/
Used Products and Services: Primary Mouse Hepatocytes, Ready-to-use Mouse Hepatocytes Plates, Hepatocytes Isolation Services from transgenic mouse model, Fresh and Cryopreserved Mouse Hepatocytes (See supplemental data and figure in this publication)
**Identification and in Vitro Characterization of a Novel BSEP and ABCB4 Dual-acting Positive Functional Modulator Targeting the Treatment of a Broad Range of Hepatobiliary Diseases
J. K. Truong1, Y. Jo1, N. Fuller1, B. Reddy1, A. Kolpak1, E. Hoch1, Y. Ren1, E. L. Bell1, P. Ng1, J. P. Miller1, A. S. Garfield1,2, R. O. Hughes1
1Rectify Pharmaceuticals, Cambridge, MA 2Present address: Rhythm Pharmaceuticals, Boston, MA
AAALS the Liver Meeting, Nov. 2024
Used Products and Services: Primary Mouse Hepatocytes, Ready-to-use Mouse Hepatocytes Plates, Hepatocytes Isolation Services from transgenic mouse model, Fresh and Cryopreserved Mouse Hepatocytes.
**Adduction to arginine detoxifies aflatoxin B1 by eliminating genotoxicity and altering in vitro toxicokinetic profiles
Blake R Rushing 1, Mustafa I Selim 1
1 Department of Pharmacology and Toxicology, East Carolina University, Brody School of Medicine, Greenville, NC, 27834, USA
Oncotarget, 2017 Dec 17;9(4):4559–4570. doi: 10.18632/oncotarget.23382, https://pmc.ncbi.nlm.nih.gov/articles/PMC5796995/
Used products and services: CACO2 permeability assay, Ready-To-Use Cell-based Permeability System,
**Feasibility Study for the Rectal Route of Administration for Gentamicin Evaluated in the Neonatal Minipig Model
David H. McAdams, Manjari Lal, Manshun Lai, Manjari Quintanar-Solares
PATH, Medical Devices and Health Technologies Group, PO Box 900922, Seattle, Washington 98109
Pharmaceutics, Drug Delivery and Pharmaceutical Technology
Journal of Pharmaceutical Sciences, Volume 109, Issue 2, February 2020, Pages 992-1001
https://www.sciencedirect.com/science/article/abs/pii/S0022354919304976
Used products and services: AssayReady™ Caco-2 Epithelial Barrier Permeability Kit, CACO2 permeability assay
**In-Vivo and Ex-Vivo Brain Uptake Studies of Peptidomimetic Neurolysin Activators in Healthy and Stroke Animals
Saeideh Nozohouri 1,2, Shiva Hadi Esfahani 1,2, Behnam Noorani 1,2,
Dhaval Patel 5, Heidi Villalba 1,2, Yashwardhan Ghanwatkar 1,2,
Md Shafikur Rahman 3, Yong Zhang 1,2, Ulrich Bickel 1,2, Paul C Trippier 3,4, Vardan T Karamyan 1,2, Thomas J Abbruscato 1,2
Department of Pharmaceutical Sciences, Jerry. H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter St, Amarillo, TX 79106, USA
Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center (UNMC), Omaha, NE 68106, USA
Pharm Res. 2022 Mar 3;39(7):1587–1598. doi: 10.1007/s11095-022-03218-w
https://pmc.ncbi.nlm.nih.gov/articles/PMC9295206
Used products and services: AssayReady™ MDR1-MDCK Epithelial Barrier Permeability System
**Permeability of Metformin across an In Vitro Blood–Brain Barrier Model during Normoxia and Oxygen-Glucose Deprivation Conditions: Role of Organic Cation Transporters (Octs)
Sejal Sharma 1,2, Yong Zhang 1,2, Khondker Ayesha Akter 1,2, Saeideh Nozohouri 1,2, Sabrina Rahman Archie 1,2, Dhavalkumar Patel 1,2, Heidi Villalba 1,2, Thomas Abbruscato 1,2,*
Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
Pharmaceutics, 2023 Apr 28;15(5):1357. doi: 10.3390/pharmaceutics15051357
https://pmc.ncbi.nlm.nih.gov/articles/PMC10220878
Used products and services: AssayReady™ MDR1-MDCK Epithelial Barrier Permeability System; MDR1-MDCK 12-well transport assay